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目的 :探讨变应性鼻炎与气道高反应性的相关性。方法 :用 1∶ 1 0 0 ( w/v)蒿属花粉对 50例变应性鼻炎和 2 0例正常者做支气管激发试验 ,分别测定两组第 1秒用力呼气量 ( FEV1) ;测血清中嗜酸性粒细胞阳离子蛋白 ( ECP)。结果 :支气管激发试验前 ,两组支气管均无症状 ,鼻炎组FEV1为 ( 70± 2 0 ) % ,对照组为 ( 85.6± 8.9) % ,两组有显著性差异 ( P <0 .0 1 ) ;支气管激发后 ,鼻炎组中 2 3例胸部有紧迫感 ,1 0例有哮鸣 ,5例有喘息 ,1 2例无症状 ,激发阳性率为 76%。对照组均无支气管症状。激发后鼻炎组 FEV1为 ( 60± 2 0 ) % ,对照组为 ( 85.6± 8.9) % ,两组有显著性差异 ( P <0 .0 5)。鼻炎组 ECP为 ( 30 .37± 1 8.92 ) μg/L,对照组为 ( 5.2 4± 3.2 3) μg/L,两组有显著性差异 ( P <0 .0 5)。结论 :变应性鼻炎不仅鼻粘膜有变态反应所致的慢性炎症 ,而且大部分气道也有慢性炎症反应而导致气道高反应性。
Objective: To investigate the correlation between allergic rhinitis and airway hyperresponsiveness. Methods: Fifty patients with allergic rhinitis and 20 normal subjects were subjected to bronchial provocation test with 1: 100 (w / v) Artemisia pollen. The forced expiratory volume in 1 second (FEV1) Serum eosinophil cationic protein (ECP). RESULTS: Before the bronchial provocation test, the bronchial was asymptomatic in both groups. FEV1 was (70 ± 20)% in the rhinitis group and (85.6 ± 8.9)% in the control group, with significant difference between the two groups (P <0.01) After bronchial provocation, there were 23 cases of thoracic urgency in rhinitis group, 10 cases of wheeze, 5 cases wheezing, 12 cases asymptomatic, and the positive rate was 76%. The control group had no bronchial symptoms. After challenge, FEV1 was (60 ± 20)% in control group and (85.6 ± 8.9)% in control group, with significant difference between the two groups (P <0.05). The ECP in rhinitis group was (30.37 ± 1 8.92) μg / L and in the control group was (5.2 4 ± 3.2 3) μg / L, there was a significant difference between the two groups (P <0.05). CONCLUSIONS: Allergic rhinitis not only has chronic inflammation caused by allergic rhinitis, but also has chronic airway inflammation that leads to airway hyperresponsiveness.