为了研究原发性肾小球疾病血一氧化氮含量变化及其作用。我们测定了 70例各种原发性肾小球疾病血一氧化氮含量 ,包括 :慢性肾炎 2 0例 ,原发性肾病综合症 15例 ,急性肾炎 10例 ,尿毒症 2 5例 ,并和 10例健康者作比较。结果 :急性肾炎明显升高 (P<0 .0 5 ) ,而慢性肾炎 ,原发性肾病综合症及尿毒症均明显下降 (P<0 .0 1,0 .0 1及 0 .0 5 )。说明 :一氧化氮在原发性肾小球疾病中的含量有双向变化。提示 :一氧化氮对原发性肾小球疾病有双重作用。 In order to study the changes of blood nitric oxide in primary glomerular disease and its role. We measured blood nitric oxide levels in 70 patients with various primary glomerular diseases including 20 with chronic glomerulonephritis, 15 with primary nephrotic syndrome, 10 with acute nephritis and 25 with uremia and 10 healthy people for comparison. Results: Acute nephritis was significantly higher (P <0.05), while chronic nephritis, nephrotic syndrome and uremia were significantly decreased (P <0.01, 0.1 and 0.05) . Description: Nitric oxide in the primary glomerular disease in two-way changes in content. Tip: Nitric oxide has a dual effect on primary glomerular disease.