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目的 在有机磷杀虫剂中毒诱发犬循环衰竭的模型上 ,研究中枢N受体拮抗剂的实验治疗学作用。方法 健康成年雄性杂种犬 ,体重 1 2～ 1 6kg。随机分为 4组 ,对照组 (A组 )、美加明组 (B组 )、阿托品组 (C组 )、阿托品和美加明 (剂量比 1 0∶1 )联用组 (D组 )。肌肉注射敌敌畏诱发循环衰竭模型 ,观察药物对其血流动力学参数的影响。结果 敌敌畏诱发犬循环衰竭时 ,平均动脉压 (MAP)由 (1 2 3 0±1 0 3)mmHg降至染毒后 (4 3 2± 1 2 )mmHg,下降了 6 6 2 % ,心率 (HR)、心室内压最大上升速率 (+dp/dtmax)、心室内压最大下降速率 (-dp/dtmax)、心肌纤维缩短速度 (Vpm)、心肌纤维缩短速率 (Vmax)、左心室收缩压 (LVSP)等与染毒前相比分别下降了 6 8 7%、 5 1 0 %、 5 0 7%、 6 7 2 %、 94 3%、 7 4 %。而B组、C组、D组在循环衰竭治疗后 1 0min左右开始与循环衰竭时相比 ,+dp/dtmax、 -dp/dtmax等心功能指标均开始明显改善 ,其中D组在循环衰竭治疗的 1 0～ 2 0min左右与其它 3组组间同时相相比 ,△MAP、△+dp/dtmax、△ -dp/dtmax、△Vpm均有显著增高。结论 神经性N受体拮抗剂美加明对有机磷杀虫剂中毒诱发的循环衰竭有明确的治疗作用 ,并与M受体拮抗剂阿托品之间存在协同增强作用
Objective To study the experimental therapeutic effect of central N receptor antagonist on the model of circulatory failure induced by organophosphate pesticide poisoning. Methods Healthy adult male hybrid dogs, weighing 12 ~ 16kg. The rats were randomly divided into 4 groups: control group (group A), metagen group (group B), atropine group (group C), atropine and methicillin (dose ratio 10: 1) group (group D). Intramuscular injection of dichlorvos induced circulatory failure model to observe the effects of drugs on its hemodynamic parameters. Results When cyclophosphamide induced circulatory failure in dogs, mean arterial pressure (MAP) decreased from (12 300 ± 1 0 3) mmHg to (42 32 ± 1 2) mmHg after treatment, down 6 6 2% HR, + dp / dtmax, -dp / dtmax, Vpm, Vmax, LV systolic pressure (HR), left ventricular systolic pressure LVSP) decreased by 68.7%, 51.0%, 57.0%, 67.2%, 94.3% and 74.4% respectively compared with that before treatment. In group B, group C and group D, cardiac function indexes such as + dp / dtmax and -dp / dtmax began to decrease at about 10 min after CPF, Compared with the other three groups, △ MAP, △ + dp / dtmax, △ -dp / dtmax and △ Vpm were all significantly increased in 10 ~ 20 minutes. Conclusions The neurotropic N-receptor antagonist mecamin has a definite therapeutic effect on the circulatory failure induced by organophosphate insecticide poisoning and has a synergistic effect with the antagonist of M receptor antagonist atropine