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为寻求防治老年性痴呆的有效措施 ,运用Morris水迷宫评价了中药补肾益智方 (由蛇床子、枸杞子、女贞子、人参等组成 )对由D_半乳糖致亚急性衰老加上Meynert核损毁所致阿尔茨海默病模型大鼠的学习记忆能力的保护作用。结果表明 :补肾益智方能够改善模型大鼠的学习记忆成绩 ,包括缩短模型大鼠在Morris水迷宫中寻找到平台的逃避潜伏期 (P <0 .0 1) ,延长其在原平台象限游泳的距离 (P <0 .0 5)。提示补肾益智方对阿尔茨海默病模型大鼠的学习记忆能力有一定的保护作用
In order to seek effective measures for preventing and treating Alzheimer’s disease, the Morris water maze was used to evaluate the traditional Chinese medicine Bushen Yizhi Recipe (composed of Cnidium, Scorpion, Ligustrum lucidum, and ginseng) on the subacute aging caused by D-galactose plus Meynert. Protective effects of nuclear damage on learning and memory in model rats with Alzheimer’s disease. The results showed that: Bushen Yizhi Recipe can improve the learning and memory performance of model rats, including shortening the escape latency of the platform in the Morris water maze (P < 0.01), and extending the swimming distance in the original platform quadrant. (P <0. 0 5). Tips Bushen Yizhi Prescription has a protective effect on learning and memory in Alzheimer’s disease model rats