论文部分内容阅读
目的探讨同型半胱氨酸在2型糖尿病肾病发生发展中的临床意义。方法选择77例2型糖尿病患者,并根据尿微量白蛋白排泄率水平将其分为单纯糖尿病组、早期糖尿病肾病组、临床糖尿病肾病组,30例健康体检者为正常对照组,检测其血同型半胱氨酸水平。采用SPSS17.0统计软件进行分析。结果各组血浆同型半胱氨酸水平相比较,糖尿病合并肾病组显著高于单纯糖尿病组,并随糖尿病肾病患者肾脏损伤程度的加重而升高,每两组间相比差异有统计学意义(P<0.01)。结论高同型半胱氨酸血症是糖尿病患者出现肾脏损害的危险因素,血浆同型半胱氨酸水平可作为糖尿病肾病病情监测的有效指标。
Objective To investigate the clinical significance of homocysteine in the development of type 2 diabetic nephropathy. Methods A total of 77 patients with type 2 diabetes mellitus were selected and divided into simple diabetic group, early diabetic nephropathy group, clinical diabetic nephropathy group and 30 healthy subjects as normal control group according to the level of urinary albumin excretion. Cysteine levels. Using SPSS17.0 statistical software for analysis. Results Plasma homocysteine level in each group was significantly higher than that in the diabetic nephropathy group and increased with the severity of renal injury in patients with diabetic nephropathy. There was a significant difference between the two groups P <0.01). Conclusion Hyperhomocysteinemia is a risk factor for kidney damage in diabetic patients. Plasma homocysteine level may be an effective indicator for the monitoring of diabetic nephropathy.