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目的评价持续皮下胰岛素注射(CSII)治疗在胰岛素脱敏治疗中的应用价值。方法对7例胰岛素过敏患者采用CSII进行脱敏治疗,以0.05U/h稀释胰岛素溶液为起始基础率,逐步增加输注速度和浓度,在此基础上调整治疗方案为餐前皮下注射胰岛素联合口服降糖药治疗。结果 7例均脱敏成功,改为皮下注射后未出现过敏反应。随访3个月,患者HbA1c、FPG和2hPG均下降(P<0.01)。结论 CSII能更好地模拟生理性胰岛素分泌,可用于胰岛素脱敏治疗。
Objective To evaluate the value of continuous subcutaneous insulin injection (CSII) in the treatment of insulin desensitization. Methods Seven cases of insulin allergy were treated with desensitization treatment with CSII. With 0.05U / h diluted insulin solution as the initial basal rate, the infusion rate and concentration were gradually increased. On this basis, the treatment regimen was subcutaneous insulin injections Oral hypoglycemic agents. Results 7 cases were successful desensitization, instead of allergic reactions after subcutaneous injection. After 3 months of follow-up, HbA1c, FPG and 2hPG decreased (P <0.01). Conclusion CSII can better simulate physiological insulin secretion and can be used in insulin desensitization therapy.