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目的探讨激素替代疗法对妊娠合并甲状腺功能减退症患者妊娠结局的影响。方法随机收集2012年12月至2014年12月87例妊娠合并甲状腺功能减退症患者为甲减组,同时选取同期50例妊娠合并亚临床甲状腺功能减退症患者为亚甲减组,以及100例甲状腺功能正常孕妇为对照组进行对比观察,给予甲减组和亚甲减组进行激素替代疗法治疗,分析三组孕妇的妊娠结局。结果亚甲减组、甲减组妊娠高血压发生率与对照组比较,差异有统计学意义(P<0.05);亚甲减组、甲减组胎膜早破发生率与对照组比较,差异有统计学意义(P<0.05)。甲减组妊娠孕周少于亚甲减组、对照组,甲减组顺产率低于对照组,差异有统计学意义(P<0.05)。结论妊娠合并甲状腺功能减退症患者在孕早期实施激素替代疗法治疗,可降低妊娠并发症发生率,改善妊娠结局,提高新生儿出生质量。
Objective To investigate the effect of hormone replacement therapy on pregnancy outcome in pregnancy complicated with hypothyroidism. Methods A total of 87 hypothyroidism patients with hypothyroidism during pregnancy from December 2012 to December 2014 were randomly divided into hypothyroidism group and 50 hypothyroidism hypothyroidism group and 50 thyroid gland samples from 50 pregnant women with subclinical hypothyroidism during pregnancy. Pregnant women with normal function as a control group were observed and compared, hypothyroidism and hypothyroidism given hormone replacement therapy, analysis of three groups of pregnant women’s pregnancy outcome. Results The incidence of pregnancy-induced hypertension in hypothyroidism group and hypothyroidism group was significantly lower than that in control group (P <0.05). The incidence of premature rupture of membranes in hypothyroidism group and hypothyroidism group was significantly lower than that in control group There was statistical significance (P <0.05). The hypothyroidism gestational weeks less than sub-sub-group, the control group, hypothyroidism cis-birth rate was lower than the control group, the difference was statistically significant (P <0.05). Conclusion Pregnancy with hypothyroidism in the first trimester of patients with hormone replacement therapy, can reduce the incidence of pregnancy complications, improve pregnancy outcomes and improve the quality of newborn birth.