Calpains是一种胞内半胱氨酸蛋白酶,主要由胞内钙离子浓度的升高所激活。近年来的研究发现calpains与细胞凋亡有关。相关试验表明,活化后的calpains可通过剪切有关凋亡分子蛋白如Bcl-2,Bax,Bid和p53等,以及直接剪切并活化caspase-3、caspase-7等方式,从而参与调控细胞凋亡的病理过程。 Calpains is an intracellular cysteine ​​protease that is primarily activated by elevated intracellular calcium concentrations. Recent studies have found that calpains and apoptosis. Related experiments show that activated calpains can participate in the regulation of cell apoptosis by cleaving the relevant apoptosis protein such as Bcl-2, Bax, Bid and p53, and directly cleaving and activating caspase-3 and caspase-7 Pathological process of death.