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[目的]探讨胃镜下喷洒生物蛋白胶联合静脉注射奥美拉唑治疗十二指肠球部溃疡活动性出血的疗效。[方法]选择2003年2月～2009年11月在某院住院治疗的77例十二指肠球部溃疡活动性出血患者作为研究对象,随机分为研究组39例和对照组38例。研究组喷洒生物蛋白胶联合静脉注射奥美拉唑,对照组仅静脉注射奥美拉唑,比较两组的疗效。[结果]研究组总有效率为94.9%,明显优于对照组,组间比较差异有统计学意义(P﹤0.05)。治疗过程中两组均未发生明显并发症。[结论]胃镜下喷洒生物蛋白胶联合静脉注射奥美拉唑治疗十二指肠球部溃疡活动性出血疗效显著,且无明显的毒副作用,值得临床推广应用。
[Objective] To investigate the efficacy of endoscopic biopioflagel spray combined with intravenous omeprazole in the treatment of active bleeding of duodenal ulcer. [Methods] A total of 77 patients with active bleeding from duodenal ulcer in a hospital from February 2003 to November 2009 were selected and randomly divided into study group (39 cases) and control group (38 cases). The study group was sprayed with bio-protein glue and intravenous injection of omeprazole, the control group only omeprazole intravenous injection, the efficacy of the two groups were compared. [Results] The total effective rate of the study group was 94.9%, which was significantly better than that of the control group. The difference between the two groups was statistically significant (P <0.05). No significant complications occurred in either group during treatment. [Conclusion] Bioactive gaspheres in combination with intravenous injection of omeprazole in the treatment of active hemorrhage of duodenal ulcer in endoscopy have significant curative effect and no obvious side effects, which is worthy of clinical application.