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目的观察硫酸头孢噻利(第4代头孢菌素类抗生素)与奥美拉唑钠(抗溃疡药)的配伍稳定性。方法用反相高效液相色谱法测定硫酸头孢噻利与奥美拉唑钠配伍后在不同温度下8 h内的相对百分含量,并考察其外观与pH值。结果硫酸头孢噻利与奥美拉唑钠配伍后,在4℃放置8 h、25℃放置3 h、37℃放置1 h,配伍溶液的外观、pH值及两者相对百分含量基本无变化。37℃放置2 h后,奥美拉唑钠相对百分含量变化约5%,配伍液不能使用。结论硫酸头孢噻利与奥美拉唑钠的配伍液在高温环境中1 h内稳定,2 h后稳定性差。
Objective To observe the compatibility of cefoselis sulfate (4th generation cephalosporin antibiotic) and omeprazole sodium (antiulcer drug) compatibility stability. Methods The relative content of ceftizurium sulfate and omeprazole sodium in 8 h at different temperatures was determined by RP-HPLC. The appearance and pH value were also investigated. Results After the compatibility of ceftizurium and omeprazole sodium for 8 h at 4 ℃, 3 h at 25 ℃ and 1 h at 37 ℃, the appearance, pH value and relative percentage of the two solutions did not change . After 2 h at 37 ℃, the relative percentage change of omeprazole sodium is about 5%, and the compatibility solution can not be used. Conclusion The compatibility of ceftiofur sulfate and omeprazole sodium is stable within 1 h at high temperature, but poor after 2 h.