The fast progress of stimuli-responsive theranostic nanomedicine can achieve the specific and highperformance diagnosis and therapy of various diseases.Especially,H_2O_2-responsive theranostic nanomedicine is recently emerging as a new stimuli-responsive modality showing the great potential for the theranostic of diseases with overexpressed H_2O_2 because H_2O_2 is associated with several kinds of human diseases as the most stable and abundant reactive oxygen species.This review summarizes and discusses the very-recent developments of H_2O_2-responsive theranostic nanoplatforms for versatile biomedical applications,including diagnostic imaging,attenuating tumor hypoxia,enhancing the therapeutic efficiency of photodynamic therapy/radiation therapy/chemotherapy and theranostic of inflammation/diabetic.The facing challenges and future developments of H_2O_2-responisve theranostics are also briefly discussed to further promote the clinical translation of this new responsive theranostic modality.It is highly believed that H_2O_2-responsive theranostic nanomedicine will be extensively developed a new specific and efficient theranostic modality to benefit the personalized biomedicine in the near future. The fast progress of stimuli-responsive theranostic nanomedicine can achieve the specific and highperformance diagnosis and therapy of various diseases.Especially, H_2O_2-responsive theranostic nanomedicine is recently emerging as a new stimuli-responsive modality showing the great potential for the theranostic of diseases with overexpressed H_2O_2 because H_2O_2 is associated with several kinds of human diseases as the most stable and abundant reactive oxygen species. This review summarizes and discusses the very-recent developments of H_2O_2-responsive theranostic nanoplatforms for versatile biomedical applications, including diagnostic imaging, attenuating tumor hypoxia, enhancing the therapeutic efficiency of photodynamic therapy / radiation therapy / chemotherapy and theranostic of inflammation / diabetic. These facing challenges and future developments of H_2O_2-responsve theranostics are also briefly discussed to further promote the clinical translation of this new responsive theranostic modality ality.It is highly believed that H_2O_2-responsive theranostic nanomedicine will be extensively developed a new specific and efficient theranostic modality to benefit the personalized biomedicine in the near future.