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目的了解浙江省丽水市新入园儿童病毒性乙型肝炎(乙肝)疫苗(HepB)接种率、乙肝病毒(HBV)感染率及其抗体阳性率。方法采集2006-2008年10 619名(2006年4052名,2007年4420名,2008年2147名)入园体检儿童外周静脉血,用ELISA法检测HBV表面抗原(HBsAg)及其抗体(抗-HBs)。采用检查疫苗接种记录了解上述儿童HepB接种情况。结果上述儿童的HepB接种率>99%。10 619份血标本中,HBsAg总阳性率为0.56%,各年度的阳性率分别为0.71%、0.52%和0.37%,呈逐年下降趋势(P>0.05)。上述标本中抗-HBs总阳性率为47.10%,其中2006、2007和2008年的血标本中抗-HBs阳性率分别为42.57%、48.21%和53.38%,抗-HBs阳性率逐年升高(P<0.01)。结论丽水市入园儿童HepB接种率很高,HBV感染率很低,且抗-HBs阳性率逐年升高,表明该市儿童的乙肝防控工作已有明显成效。
Objective To investigate the vaccination rate of hepatitis B virus (HepB), the rate of hepatitis B virus (HBV) infection and the positive rate of antibody in newly admitted children in Lishui City, Zhejiang Province. Methods A total of 10 619 children (4052 in 2006, 4420 in 2007 and 2147 in 2008) were enrolled in this study. Peripheral venous blood samples were collected from children admitted to the hospital from 2006 to 2008. HBsAg and anti-HBs ). Check the vaccination records to understand the HepB vaccination of children. Results The HepB vaccination rates for these children were> 99%. The positive rate of HBsAg in 10 619 blood samples was 0.56%. The positive rates of HBsAg in each year were 0.71%, 0.52% and 0.37% respectively, showing a declining trend year by year (P> 0.05). The positive rate of anti-HBs in the above specimens was 47.10%. The positive rates of anti-HBs in blood samples were 42.57%, 48.21% and 53.38% respectively in 2006, 2007 and 2008, and the positive rate of anti-HBs was increased year by year <0.01). Conclusion Hepatitis B vaccination rate is very high in children admitted to Lishui City, HBV infection rate is very low, and the positive rate of anti-HBs is increasing year by year, indicating that the city’s hepatitis B prevention and control work has achieved remarkable results.