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目的:检测酒精性肝硬化患者血清同型半胱氨酸(Hcy)的水平,探讨血清Hcy水平与酒精性肝硬化的相关关系。方法:选择肝炎后肝硬化62例、酒精性肝硬化18例、混合性肝硬化27例及健康人群50例,测定血清同型半胱氨酸、叶酸、维生素B12(VitB12)、丙氨酸氨基转移酶(ALT)、γ-谷氨酰转肽酶(GGT)的水平。结果:酒精性肝硬化患者血清同型半胱氨酸水平明显升高(P<0.01),酒精性肝硬化患者较肝炎后肝硬化患者明显升高(P<0.05);血清同型半胱氨酸水平与酒精性肝硬化患者Child-Turcotte-Pugh得分呈负相关(r=-0.586,P<0.05)。结论:肝硬化患者血清Hcy水平显著升高,且其在酒精性肝硬化患者中升高更为显著。酒精性肝硬化患者随着肝脏损伤程度的逐渐增加,血清Hcy水平逐渐降低。
Objective: To detect the level of serum homocysteine (Hcy) in patients with alcoholic cirrhosis and to explore the relationship between serum Hcy level and alcoholic cirrhosis. Methods: Sixty-two cases of post-hepatitis cirrhosis, 18 cases of alcoholic cirrhosis, 27 cases of mixed cirrhosis and 50 healthy people were enrolled in this study. Serum levels of homocysteine, folic acid, vitamin B12 (VitB12), alanine aminotransferase Enzyme (ALT), γ-glutamyl transpeptidase (GGT) levels. Results: Serum homocysteine levels were significantly elevated in patients with alcoholic cirrhosis (P <0.01), patients with alcoholic cirrhosis were significantly higher than those in patients with posthepatitis cirrhosis (P <0.05), serum homocysteine levels There was a negative correlation between Child-Turcotte-Pugh score and alcoholic cirrhosis (r = -0.586, P <0.05). Conclusions: Serum Hcy levels are significantly elevated in cirrhotic patients and are more pronounced in patients with alcoholic cirrhosis. Patients with alcoholic liver cirrhosis gradually increase with the degree of liver injury, serum Hcy levels gradually decreased.