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由于膀胱癌复杂的致病因素和经治疗后难以控制的局部复发或转移,迫切需要研究新的有效的治疗方法。姜黄素(curcumin)是姜黄的主要活性成分之一,它通过抑制N F-κB的激活以及下调N F-κB调节的基因产物,调节肿瘤相关蛋白的表达等机制发挥抗肿瘤作用和预防肿瘤的复发。姜黄素凭借其多元化的抗肿瘤机制以及价格低廉和低毒副作用等特点,吸引了大批学者进行其治疗膀胱癌的相关研究。本文对姜黄素在膀胱癌治疗中的研究作一综述。
Due to the complex causative factors of bladder cancer and the uncontrolled local recurrence or metastasis after treatment, it is urgent to study new effective treatments. Curcumin, one of the main active components of turmeric, exerts antitumor effects and tumor prevention by inhibiting the activation of NF-κB and down-regulating NF-κB regulated gene products and regulating the expression of tumor-associated proteins relapse. Curcumin has attracted a large number of scholars to study its treatment of bladder cancer due to its diverse anti-tumor mechanism, low price and low toxicity and side effects. This article summarizes the research of curcumin in the treatment of bladder cancer.