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目的:探讨急性心肌梗死(AMI)患者静脉尿激酶(UK)溶栓治疗的时效性。方法:按发病时间将95例AMI患者分为2组:6:01(am)～12:00(am)组(上午组),42例;12:01(am)～次日6:00(am)组(其他时间组):53例。记录2组患者再通率,观察抗凝指标及纤溶指标。结果:上午组与其他时间组溶栓再通率分别为54.8%、75.5%,2组比较差异有统计学意义(P<0.05)。结论:AMI早期UK溶栓存在晨起抵抗现象,其原因可能与纤溶酶原激活物抑制物-1抗原及活性增高有关。
Objective: To investigate the timeliness of intravenous urokinase (UK) thrombolysis in patients with acute myocardial infarction (AMI). Methods: Ninety-five patients with AMI were divided into two groups according to the time of onset: 42 patients in the morning of 6: 01 (am) ~ 12: 00 am group, 12: 01 (am) to 6:00 in the next day am group (other time groups): 53 cases. Record two groups of patients recanalization rate, observed anticoagulation index and fibrinolytic index. Results: The rate of thrombolysis recanalization was 54.8% and 75.5% respectively in the morning group and other time groups. The difference between the two groups was statistically significant (P <0.05). CONCLUSION: Early AMI thrombolysis in early AMI may have early morning resistance, which may be related to the increase of plasminogen activator inhibitor-1 antigen and its activity.