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目的 探讨糖皮质激素在严重急性呼吸综合征 (SARS)治疗中的作用。方法 对 2 0 0 3年 3月至 5月在本院收治的 70例SARS患者进行分析。结果 (1) 70例患者治愈出院 6 3例 ,死亡 7例 ,平均住院 16 9d。 (2 )激素治疗 :11例未接受激素治疗 ,平均住院 16 8d ;5 9例采用甲泼尼龙 4 0～ 6 4 0mg/d ,其中小剂量组 2 3例 ,4 0～ 80mg/d ,平均住院 15d ;中剂量组 2 7例 ,治疗剂量 12 0～ 2 4 0mg/d ,平均住院 18 5d ;大剂量组 9例 ,32 0～ 6 4 0mg/d ,平均住院 17 9d。 结论 早期、适量使用糖皮质激素能明显改善SARS患者的临床症状 ,减轻病变进展程度 ,加快肺部病变的吸收。但目前的数据显示 ,使用糖皮质激素不能缩短住院时间。
Objective To investigate the role of glucocorticoids in the treatment of severe acute respiratory syndrome (SARS). Methods Seventy SARS patients admitted to our hospital from March to May in 2003 were analyzed. Results (1) 70 patients were cured and discharged 63 cases, 7 died, the average hospitalized 16 9 days. (2) hormone therapy: 11 cases did not receive hormone therapy, the average hospital stay 16d; 59 cases of methylprednisolone 40 ~ 6 40mg / d, of which 23 cases of low-dose group, 40 ~ 80mg / d, Hospitalized 15d; medium-dose group of 27 cases, the therapeutic dose of 120 ~ 240mg / d, the average hospital 18d; high-dose group 9 cases, 320 ~ 640mg / d, the average hospital stay 17d. Conclusion Early use of proper amount of glucocorticoids can significantly improve the clinical symptoms of patients with SARS, reduce the degree of progression of the disease and accelerate the absorption of lung lesions. However, the current data show that the use of glucocorticoids can not shorten the length of stay.