本文用放射免疫分析法测定了大鼠在热及冷环境、苯丙胺兴奋和骨折等四种应激状态下脑内亮-脑啡肽(LEK)含量的变化。观察到热及冷环境和苯丙胺兴奋均使下丘脑和纹状体LEK 含量明显下降,而骨折使纹状体和丘脑 LEK 含量明显上升。这一结果说明,在四种不同的应激状态下,脑区 LEK 含量变化的趋向不尽相同。 In this paper, we measured the content of enkephalin-enkephalin (LEK) in rat brain under four kinds of stress states including fever and cold environment, amphetamine stimulation and fracture by radioimmunoassay. It was observed that both hot and cold conditions and amphetamine-induced excitability resulted in a significant decrease in LEK content in the hypothalamus and striatum, whereas fractures markedly increased LEK levels in the striatum and thalamus. This result shows that in four different stress states, brain LEK content trends vary.