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近年来发现用干扰素处理过的细胞胞浆提取物和双链RNA、ATP一起培养,可以生成一个低分子量的蛋白合成抑制剂,即5′-三磷酸-三聚2′,5′-腺苷酸(Ⅰ)。由于(Ⅰ)具有天然核酸中不存在的2′,5′-磷酸酯链以及它的抗病毒活性,因此引起不少化学家的兴趣,已有不少文章报导了(Ⅰ)及其类似物的合成,同时也发现不含三磷酸的三聚2′,5′-腺苷酸(Ⅱ)也同样具有活性。为了进一步研究(Ⅰ)的结构与活性关系,本文报导了用胞嘧啶碱基代替腺嘌呤碱基的(Ⅱ)的类似物C_(2′P5′)C_(2′P5′)A(Ⅲ)的合成。
In recent years, it has been found that a cytosolic cytoplasmic extract treated with interferon can be incubated with double-stranded RNA and ATP to produce a low molecular weight protein synthesis inhibitor, 5’-triphosphate-trimeric 2 ’, 5’-gland Glycine (Ⅰ). Since (I) has a 2 ’, 5’-phosphate chain not present in natural nucleic acids and its antiviral activity, it has attracted the interest of many chemists. Many articles have reported (I) and its analogs The synthesis of trimeric 2 ’, 5’-adenylate (II) which is free of triphosphate is also found to be equally active. In order to further study the relationship between the structure and activity of (I), the analogues C (2’P5 ’) C - (2’P5’) A (Ⅲ) with cytosine bases instead of adenine bases were reported. Synthesis.