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目的对以埃索美拉唑和奥美拉唑为基础的1周三联疗法根治幽门螺杆菌的疗效进行系统性分析。方法联机检索从Medline数据库(2000年~2005年)、维普(2000~2005年)、万方数据库(2000~2005年)中检索埃索美拉唑与奥美拉唑为基础的三联疗法对根治幽门螺杆菌疗效的随机对照临床试验。对各项研究中疗效的比值比(OR)进行荟萃分析,采用Mantel-Haesul方法。结果共有7项研究符合入选标准。荟萃结果表明以埃索美拉唑为基础的1周标准三联疗法对幽门螺杆菌的根治疗效和以奥美拉唑为基础的标准三联疗法疗效相似[OR(95%CI):1·2746(0·8835,1·8388)]。结论埃索美拉唑作为奥美拉唑的光学异构体,以其为基础的1周三联疗法能有效地根治幽门螺杆菌,疗效相似于奥美拉唑。
OBJECTIVE: To systematically analyze the curative effect of triple therapy with esomeprazole and omeprazole for the radical cure of Helicobacter pylori. Methods The online search of triple therapy based on esomeprazole and omeprazole in Medline database (2000 ~ 2005), VIP (2000 ~ 2005) and Wanfang database (2000 ~ 2005) Randomized controlled clinical trial on the efficacy of Helicobacter pylori. A meta-analysis of odds ratios (ORs) for the efficacy of each study, using the Mantel-Haesul method. Results A total of seven studies met the inclusion criteria. A meta-analysis showed that esomeprazole-based 1-week standard triple therapy was equally effective in the treatment of H. pylori compared with standard triple therapy based on omeprazole [OR (95% CI): 1.2746 ( 0 · 8835, 1 · 8388)]. Conclusion As the optical isomer of omeprazole, esomeprazole can effectively cure Helicobacter pylori with 1 week triple therapy and its efficacy is similar to that of omeprazole.