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目的 建立以WHO指南为基础的结核病细菌学耐药监测系统 ,掌握宁波市初治涂阳肺结核的耐药水平。 方法 采用整群抽样方法于 1999年 10月至 2 0 0 0年 3月选择全市所有新发涂阳病例 ,并对其全部培养阳性的菌株进行菌型鉴定及 4种抗结核药物 (INH、SM、RFP、EMB)的耐药测试。 结果 初治耐药率为 17.87% ,初治耐多药率为 3 .40 % ;耐药率高低与病人的性别、年龄无关 (P >0 .0 5 )。 结论 宁波市结核病的初治耐药率处于较高水平 ,须进一步加强全市的结核病控制工作
Objective To establish a tuberculosis bacteriological drug resistance surveillance system based on WHO guidelines and to master the drug resistance level of newly diagnosed smear positive pulmonary tuberculosis in Ningbo. Methods The cluster smear method was used to select all the newly smeared smear positive cases of the city from October 1999 to March 2000. All strains positive for culture were identified by mycobacteria and four anti-TB drugs (INH, SM , RFP, EMB) resistance test. Results The initial drug resistance rate was 17.87% and the initial drug resistance rate was 3.40%. The drug resistance rate was not related to the patient’s sex and age (P> 0.05). Conclusion The initial treatment rate of tuberculosis in Ningbo is at a high level, and the city’s tuberculosis control work needs to be further strengthened