DNA甲基化属于表观遗传修饰的一种,是真核细胞DNA最普遍的修饰方式,可以通过影响基因突变、表达调控、细胞增殖等调节基因转录活性和表达。研究发现基因启动子甲基化的程度直接影响基因的转录活性,并且呈负相关。由于肿瘤的形成从本质上讲就是细胞原癌基因的激活和抑癌基因的失 DNA methylation is a kind of epigenetic modification. It is the most common modification way of DNA in eukaryotic cells. It can regulate gene transcription activity and expression by affecting gene mutation, expression regulation and cell proliferation. The study found that the degree of gene promoter methylation directly affects the transcription activity of genes, and was negatively correlated. Since the formation of tumors is essentially the activation of the protooncogene and the loss of the tumor suppressor gene