一项涉及全球47个国家的大型研究表明,心房颤动(AF)发病后的死亡及卒中风险存在难以解释的地区差异。研究者对2007年12月~2011年10月来自47个国家164个中心的15 400例AF或心房扑动患者进行了长达12年的随访分析,最终共计15 361例患者完成随访。随访1年时,共计604例(4%)患者罹患卒中,总死亡率为11%。进一步分析发现,与首次被诊断为AF者相比,再发AF患者随访1年时的卒中发生率及死亡率均更高(5%vs.3%,P<0.001和16%vs.6%,P<0.001)。此外,各地区AF患者随访1年时的卒中发 A large study of 47 countries around the world shows that there are unexplained regional differences in the rate of death and stroke after atrial fibrillation (AF). The investigators conducted a 12-year follow-up analysis of 15 400 patients with AF or atrial flutter from 164 centers in 47 countries from December 2007 to October 2011. A total of 15 361 patients were followed up. A total of 604 patients (4%) developed stroke at 1 year of follow-up, with a total mortality of 11%. Further analysis found that the incidence of stroke and mortality was higher at 1 year of follow-up compared with those who were initially diagnosed as having AF (5% vs.3%, P <0.001 and 16% vs.6% , P <0.001). In addition, AF patients in each region were followed up for stroke at 1 year