【摘 要】
：
当小鼠或大鼠在器官发生期间内暴露于麻醉剂量浓度(25,000～37,000 ppm) 的氯仿达1小时,见有高度的胚胎毒作用。本研究目的为检定怀孕大鼠暴露于工业上或化验室内氯仿的近似浓
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当小鼠或大鼠在器官发生期间内暴露于麻醉剂量浓度(25,000～37,000 ppm) 的氯仿达1小时,见有高度的胚胎毒作用。本研究目的为检定怀孕大鼠暴露于工业上或化验室内氯仿的近似浓度水平时,是否对其胚胎或胎儿发育有危害作用。使怀孕大鼠在孕期的第6～15日暴露于30、100或300 ppm,氯仿(均为麻醉作用以下的低浓度)中,每日7小时。接触氯仿引起受孕率明显地降低和胎儿吸回发生率升高(300
High mouse embryotoxicity was observed when mice or rats were exposed to chloroform at anesthetic concentrations (25,000 to 37,000 ppm) for 1 hour during organogenesis. The purpose of this study was to determine if exposure of pregnant rats to industrial or laboratory chloroform at an approximate level of concentration may have detrimental effects on their embryonic or fetal development. Pregnant rats were exposed to 30, 100 or 300 ppm on days 6-15 of pregnancy, and chloroform (all at low concentrations below the anesthetic effect) for 7 hours daily. Exposure to chloroform caused a marked decrease in the rate of conception and an increase in the rate of fetal aspiration (300
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