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目的从蛋白水平探讨Bikunin,又称尿胰蛋白酶抑制剂(urinary trypsin inhibitor,UTI)在上皮性卵巢癌浸润、转移中的作用,及其在组织中的分布情况、与预后的关系。方法应用免疫组化法检测80份上皮性卵巢癌、20份良性卵巢肿瘤标本中Bikunin蛋白表达,并结合临床病理因素、预后进行分析。结果上皮性卵巢癌、良性卵巢肿瘤标本中Bikunin阳性率分别为55.0%、20.0%,两者差异有统计学意义(χ2=7.853,P=0.005)。上皮性卵巢癌中,Bikunin阳性与国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)分期早有显著性相关,差异有统计学意义(χ2=5.241,P=0.022),与上述其他临床病理因素差异无统计学意义(P>0.05)。多因素Cox回归模型显示,Bikunin表达是总生存的独立危险因素。结论上皮性卵巢癌中Bikunin表达上调,Bikunin有可能作为预测上皮性卵巢癌预后的参考指标。
Objective To investigate the relationship between the expression of Bikunin, also known as urinary trypsin inhibitor (UTI) in epithelial ovarian cancer, invasion and metastasis, and its distribution in tissues from the protein level and its prognosis. Methods Immunohistochemistry was used to detect the expression of Bikunin protein in 80 specimens of epithelial ovarian cancer and 20 specimens of benign ovarian tumors. The expression of Bikunin protein was analyzed by clinicopathological factors and prognosis. Results The positive rates of Bikunin in epithelial ovarian cancer and benign ovarian tumor were 55.0% and 20.0%, respectively (χ2 = 7.853, P = 0.005). Epithelial ovarian cancer, Bikunin positive and the International Federation of Gynecology and Obstetrics (FIGO) staging had a significant correlation, the difference was statistically significant (χ2 = 5.241, P = 0.022), with the other clinical No significant difference in pathological factors (P> 0.05). Multivariate Cox regression model showed that Bikunin expression was an independent risk factor for overall survival. Conclusions Bikunin expression is upregulated in epithelial ovarian cancer, and Bikunin may be used as a reference index to predict the prognosis of epithelial ovarian cancer.