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目的探讨生长抑素、乌司他丁联合早期肠内营养治疗重症胰腺炎的临床效果。方法 90例重症胰腺炎患者,随机分为观察组和对照组,每组45例。对照组采用生长抑素治疗,观察组在此基础上给予乌司他丁联合早期肠内营养治疗。对比分析两组患者的临床效果。结果观察组患者治疗总有效率(91.11%)优于对照组(73.33%),差异具有统计学意义(P<0.05)。观察组患者腹痛腹胀缓解时间、白细胞恢复时间、血清淀粉酶恢复时间及住院时间均短于对照组,差异具有统计学意义(P<0.05)。治疗后观察组患者的血及尿淀粉酶、血钙、白细胞计数均优于对照组,差异具有统计学意义(P<0.05)。观察组患者不良反应总发生率为24.44%,与对照组的28.89%对比,差异无统计学意义(P>0.05)。结论生长抑素、乌司他丁联合早期肠内营养治疗急性重症胰腺炎,可有效缓解腹胀腹痛症状,并缩短血清淀粉酶、白细胞恢复时间、住院治疗时间,对急性重症胰腺炎的治疗更有效果,治愈率也更高,建议在临床治疗中大量应用。
Objective To investigate the clinical effects of somatostatin and ulinastatin combined with early enteral nutrition in the treatment of severe pancreatitis. Methods Ninety patients with severe acute pancreatitis were randomly divided into observation group and control group, with 45 cases in each group. The control group was treated with somatostatin, the observation group was treated with ulinastatin combined with early enteral nutrition. Comparative analysis of two groups of patients clinical effect. Results The total effective rate (91.11%) in observation group was better than that in control group (73.33%), the difference was statistically significant (P <0.05). The patients in the observation group had shorter durations of abdominal distension, recovery of leukocytes, recovery of serum amylase and length of hospital stay than those in the control group (P <0.05). After treatment, the blood and urine amylase, serum calcium and leukocyte counts in the observation group were better than those in the control group, with statistical significance (P <0.05). The total incidence of adverse reactions in the observation group was 24.44%, which was not significantly different from that in the control group (28.89%) (P> 0.05). Conclusions Somatostatin and ulinastatin combined with early enteral nutrition in the treatment of acute severe pancreatitis can effectively relieve symptoms of abdominal distension and abdominal pain, and shorten serum amylase, leukocyte recovery time, hospitalization time, and more in the treatment of acute severe pancreatitis Effect, the cure rate is also higher, it is recommended in a large number of clinical treatment.