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目的研究血清学指标联合检测在乳腺癌早期诊断中的价值。方法将乳腺癌患者纳入观察组、乳腺良性疾病患者纳入良性对照组、健康体检者纳入健康对照组,检测外周血中CEA、CA125、CA153和CA199的含量。结果观察组患者CEA、CA125、CA153、CA199水平明显高于良性对照组和健康对照组,并且与TNM分期呈正相关关系;四项指标联合检查的灵敏度为93.33%、特异度为91.25%,均高于四项指标单独检测。结论 CEA、CA125、CA153和CA199含量与肿瘤的TNM分期相关,联合检查能提高诊断的灵敏度和特异度,在乳腺癌的早期诊断中具有积极的临床价值。
Objective To study the value of combined serological detection in the early diagnosis of breast cancer. Methods Breast cancer patients were included in the observation group, benign breast disease patients were included in the benign control group, healthy subjects were included in the healthy control group, the detection of peripheral blood levels of CEA, CA125, CA153 and CA199. Results The levels of CEA, CA125, CA153 and CA199 in observation group were significantly higher than those in benign control group and healthy control group, and were positively correlated with TNM stage. The sensitivity and specificity of the four indexes were 93.33% and 91.25% respectively The four indicators were tested separately. Conclusions The levels of CEA, CA125, CA153 and CA199 are correlated with the TNM stage of the tumor. Combined examination can improve the sensitivity and specificity of the diagnosis, and has a positive clinical value in the early diagnosis of breast cancer.