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目的观察5-氨基酮戊酸光动力疗法、手术及咪喹莫特联合治疗皮肤基底细胞癌的临床疗效。方法将基底细胞癌患者138例随机分为A、B、C 3组各46例。A组采用5-氨基酮戊酸光动力疗法、手术及咪喹莫特联合,B组采用5-氨基酮戊酸光动力疗法与手术联合,C组采用5-氨基酮戊酸光动力疗法与咪喹莫特联合。比较3组临床疗效,伤口愈合情况及不良反应发生情况。结果 A组总有效率、伤口一期愈合率明显高于B、C组,二期愈合率、不良反应发生率明显低于B、C组,差异均有统计学意义(P<0.05)。B组和C组一期愈合、二期愈合情况及不良反应发生率比较差异均无统计学意义(P>0.05)。结论 5-氨基酮戊酸光动力疗法、手术及咪喹莫特联合对皮肤基底细胞癌进行治疗,临床疗效较好,一期愈合率较高,且安全性较高,具有较高价值。
Objective To observe the clinical efficacy of 5-aminolevulinic acid photodynamic therapy combined with surgery and imiquimod in the treatment of cutaneous basal cell carcinoma. Methods 138 patients with basal cell carcinoma were randomly divided into A, B, C 3 group of 46 cases. A group using 5-aminolevulinic acid photodynamic therapy, surgery and imiquimod combined, B group using 5-aminolevulinic acid photodynamic therapy combined with surgery, C group using 5-aminolevulinic acid photodynamic therapy and Imiquimod joint. The clinical efficacy, wound healing and adverse reactions of the three groups were compared. Results The total effective rate of group A was significantly higher than that of group B and C (P <0.05). The rate of second-phase healing and adverse reaction was significantly lower than that of B and C groups (P <0.05). There was no significant difference between group B and group C in primary healing, secondary healing and incidence of adverse reactions (P> 0.05). Conclusions 5-Aminolevulinic acid photodynamic therapy combined with operation and imiquimod is effective in the treatment of cutaneous basal cell carcinoma. The clinical efficacy is better, the rate of primary healing is higher, the safety is higher and the value is higher.