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研究发现恶性血液病细胞高表达血管内皮生长因子(vascular endothelial growth factor,VEGF),并不同程度表达VEGF受体[1~2],VEGF在白血病中的作用不够明确,可能是通过自分泌作用机制,促进白血病细胞存活和生长、降低白血病细胞对化疗药物的敏感性等。以前的研究已证实:VEGF反义
The study found that hematopoietic malignant cells highly express vascular endothelial growth factor (VEGF) and express VEGF receptors to varying degrees [1 ~ 2]. The role of VEGF in leukemia is not clear enough, probably through the mechanism of autocrine , Promote the survival and growth of leukemia cells and reduce the sensitivity of leukemia cells to chemotherapy drugs. Previous studies have confirmed: VEGF antisense