托吡酯对不同类型脑缺血、脑外伤、癫痫、神经系统变性、偏头痛等疾病动物模型具有神经保护作用,并且存在空间、时间依赖性,已被临床用于治疗糖尿病周围神经病、头痛、神经性疼痛和特发性震颤。托吡酯神经保护机制的研究仍处于临床前阶段,可能与减少兴奋性氨基酸释放、调节γ氨基丁酸受体活性、阻断电压依赖性钠离子通道、减轻细胞内Ca2+超载以及促进轴突生长等作用有关。 Topiramate has neuroprotective effects on animal models of various types of cerebral ischemia, traumatic brain injury, epilepsy, nervous system degeneration, migraine and the like, and has space-time and time dependence. It has been clinically used to treat diabetic peripheral neuropathy, headache and neurosis Pain and idiopathic tremor. The mechanism of topiramate neuroprotection is still in the preclinical stage, which may be related to the reduction of excitatory amino acid release, the modulation of γ-aminobutyric acid receptor activity, the blockade of voltage-dependent sodium channel, the reduction of intracellular Ca2 + overload and the promotion of axonal growth related.