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用高压液相色谱法测定了肝脏缺血再灌注后ATP含量的变化。应用预防损伤的药物氯丙嗪和异博定后 ,兔肝组织ATP含量明显高于不用药的对照组 ,说明钙离子拮抗剂有预防缺血再灌注损伤的作用 ,其作用机理与减少钙离子内流 ,维持和促进细胞能量代谢的正常有关。
The changes of ATP content after hepatic ischemia-reperfusion were determined by high pressure liquid chromatography. Application of prophylactic trauma drugs chlorpromazine and isoproturine, rabbit liver ATP content was significantly higher than the control group, indicating that calcium antagonists have the role of prevention of ischemia-reperfusion injury, its mechanism of action and reduce calcium Internal flow, to maintain and promote normal cellular energy metabolism.