本文论述在造血系统肿瘤、特别是淋巴系统肿瘤研究中,Ig,TCR 基因探针的应用以及如何直接应用 DNA 杂交技术来检测白血病细胞中染色体的异常。这种方法优于细胞遗传学技术。同时,DNA 探针对区别白血病病人骨髓移植后供者和宿主的细胞群体也是一种敏感的方法。这使骨髓研究、检测白血病复发的起源细胞及对造血组织和淋巴组织嵌合状态的诊断等成为可能。 This article discusses the application of Ig and TCR gene probes in hematopoietic tumor, especially lymphatic system tumor research and how to directly detect chromosomal abnormalities in leukemia cells by using DNA hybridization directly. This method is superior to cytogenetics. In the meantime, DNA probes are also a sensitive method for differentiating donor and host cell populations after bone marrow transplantation in patients with leukemia. This makes it possible for bone marrow research to detect the origin cells of leukemia relapse and to diagnose the chimerism status of hematopoietic tissues and lymphoid tissues.