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目的探讨31例甲状腺癌临床病理特点、诊断及鉴别诊断要点。方法回顾性分析2004年-2008年5年间病理科诊断明确的甲状腺滤泡癌的病理组织学特点及免疫组化结果。结果甲状腺滤泡癌是由各种不同分化程度的滤泡构成的肿瘤,癌细胞核致密深染,常有包膜及血管浸润。免疫组化标记结果:本组31例TG、TTF-1、CD34(血管)均阳性,13例CK19阳性,13例HMBE-1阳性,7例P53阳性,8例PCNA阳性,Calcitonin均阴性。结论甲状腺滤泡癌的诊断肯定有包膜浸润、血管侵犯或甲状腺外的转移的证据之一。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of 31 thyroid carcinomas. Methods The histopathological features and immunohistochemical results of thyroid follicular carcinoma diagnosed in the pathology department during 2004-2008 were retrospectively analyzed. Results Thyroid follicular carcinoma is a tumor composed of follicles with different degrees of differentiation. The nuclei of cancer cells are dense and deeply stained, often with capsule and vascular infiltration. Immunohistochemical results: 31 cases of TG, TTF-1, CD34 (blood vessels) positive, 13 CK19 positive, 13 HMBE-1 positive, 7 P53 positive, 8 PCNA positive, Calcitonin negative. Conclusion The diagnosis of thyroid follicular carcinoma certainly has evidence of envelope invasion, vascular invasion or extrathyroidal metastasis.