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目的：探讨不同的蝎毒抗癌多肽（ＡＰＢＭＶ）制剂经不同的给药途径对肿瘤及免疫的影响，并为ＡＰＢＭＶ制剂的临床应用提供实验依据。方法：肝癌（Ｈ２２）荷瘤小鼠６５只，雄性，体重（２０±２）ｇ，分别给予ＡＰＢＭＶ３种制剂（针剂、胶囊及乳剂）及５氟尿嘧啶（５Ｆｕ），给药１０ｄ后处死，观察外周血白细胞数、瘤块及脾脏重量的变化。结果：５Ｆｕ对Ｈ２２荷瘤小鼠肿瘤的抑制最高，可达４８．８１％；ＡＰＢＭＶ针剂对肿瘤的抑制率亦达４０．５９％，与阴性对照相比，差异均有显著性（Ｐ＜０．０５）。ＡＰＢＭＶ乳剂、针剂及胶囊组的脾重指数分别为７４．２７ｍｇ／１０ｇ、７１．４２ｍｇ／１０ｇ及７３．３１ｍｇ／１０ｇ，与阴性对照组相比，均有显著增加（Ｐ＜０．０１）。ＡＰＢＭＶ乳剂及胶囊组的白细胞数目分别达到１４．２１×１０９Ｌ－１、１４．３６×１０９Ｌ－１，与阴性对照组相比，均有显著增加（Ｐ＜０．０１）；而ＡＰＢＭＶ针剂组的白细胞数目为１０．４１×１０９Ｌ－１，虽与阴性对照组相似，但较阳性对照组显著增加（Ｐ＜０．００１）。结论：ＡＰＢＭＶ３种制剂均可抑制肿瘤的生长、促进脾脏功能、升高白细胞数目及增强机体免疫能力。在实际应用过程中，ＡＰＢＭ?
OBJECTIVE: To investigate the effects of different preparations of APBMV on tumor and immune via different route of administration, and to provide experimental basis for the clinical application of APBMV. Methods: Tumor-bearing mice (H22), 65, male, weighing 20 ± 2 g, were given APBMV 3 kinds of preparation (injection, capsule and emulsion) and 5-fluorouracil , Observed the number of peripheral white blood cells, tumor mass and spleen weight changes. Results: 5Fu had the highest inhibitory effect on tumors in H22 tumor-bearing mice (up to 48.81%). The inhibitory rate of APBMV on tumor was 40.59%, which was significantly different from that of negative control (P <0.05). The spleen indexes of APBMV emulsion, injection and capsule group were 74.27mg / 10g, 71.42mg / 10g and 73.31mg / 10g, respectively, which were significantly increased compared with the negative control group (P <0.01). The number of leukocytes in APBMV emulsion and capsule groups were 14.21 × 109L-1 and 14.36 × 109L-1, respectively, which were significantly higher than those in the negative control group (P <0.01) The number of white blood cells was 10.41 × 109 L-1, which was similar to the negative control group but significantly higher than that of the positive control group (P <0.001). Conclusion: APBMV 3 kinds of agents can inhibit tumor growth, promote spleen function, increase the number of white blood cells and enhance immunity. In the practical application process, APBM?