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The coronavirus disease 2019 (COVID-19) pandemic contin-ues worldwide. We report here two cases of chronic hepati-tis B patients with acute respiratory syndrome coronavirus 2 infection treated with tenofovir disoproxil fumarate who demonstrated a favorable outcome. This report adds some evidence that concurrent HBV infection may not worsen COVID-19 infection and tenofovir disoproxil fumarate treat-ment may have partial positive effect on COVID-19 rapid recovery.