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为研究高温、噪声及复合因素对大鼠血浆及肺组织中内皮素(ET)含量的影响,用特异性放射免疫法对80只Wistar大鼠进行检测(每组暴露1h).结果:(1)对照组、高温组、噪声组及复合因素组血浆ET含量分别为821.5±49.3、786.8±46.0、823.6±58.6及703.1±29.6pg/mL,复合因素组血浆ET含量较对照组明显下降(P<0.05).(2)对照组、高温组、噪声组及复合因素组肺ET含量分别为21.6±7.6、53.6±15.1、45.1±7.1及17.2±2.3pg/mg ww,噪声组肺ET含量较对照组明显升高(P＜0.05)。噪声组肺ET含量明显升高与噪声使交感神经紧张性增加,肺组织缺氧有关.ET是目前已知最强的支气管收缩剂,故强噪声可引发支气管哮喘.ET对心肌具有剂量依赖性正性肌力作用,可使血浆中加压素,肾上腺素水平增加,复合因素组血浆ET含量下降可能会使心肌收缩力减弱,血压下降,进而出现心慌、头晕、疲乏等症状,使工作耐力下降.
In order to study the effect of high temperature, noise and compound factors on the content of ET in plasma and lung tissue of rats, 80 Wistar rats were exposed to specific radioimmunoassay (1h exposure to each group) .Results: ) Plasma ET levels were 821.5 ± 49.3, 786.8 ± 46.0, 823.6 ± 58.6 and 703.1 ± 29.6 pg / mL in the control group, the high-temperature group, the noise group and the composite group, respectively. The ET content in the composite group was significantly lower than that in the control group <0.05). (2) The content of lung ET in the control group, high temperature group, noise group and combination group were 21.6 ± 7.6,53.6 ± 15.1,45.1 ± 7.1 and 17.2 ± 2.3pg / mg ww, respectively The control group was significantly higher (P <0.05). ET significantly increased noise in the lungs and the noise increased sympathetic tone, lung tissue hypoxia.ET is the strongest known bronchoconstrictor, so the strong noise can cause bronchial asthma.ET has a dose-dependent myocardial Positive inotropic effect can make the plasma vasopressin, adrenaline levels increased, decreased plasma ET levels in composite factor group may reduce myocardial contractility, blood pressure, then there palpitation, dizziness, fatigue and other symptoms, so that work endurance decline.