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目的探讨乙肝疫苗免疫失败机制。方法对全程乙肝疫苗接种后抗体检测仍为阴性者(免疫失败)进行HBVDNA检测、免疫失败者及加强免疫对照进行生活习惯等影响因素病例调查研究。结果15例对象中发现1例HBVDNA阳性;条件单因素回归分析结果表明接种对象的性别、饮酒史、身高、体重、家族史病例组与对照组之间差异有统计学意义(P<0.05),条件多因素逐步回归分析有三种因素进入回归方程,接种对象的性别、家族史、饮酒情况有差异。男性发生免疫失败的概率是女性的1.79倍,有家族史对象免疫失败的概率为无家族史对象的4.98倍,每周饮酒2两以上对象是很少喝酒对象的1.58倍。结论本研究结果表明,接种对象的微量HBV感染、性别、家族史、饮酒情况为乙肝疫苗失败的影响因素。
Objective To investigate the mechanism of immune failure of hepatitis B vaccine. Methods HBVDNA test, immunocompromised and immunocompromised controls were used to investigate the influencing factors such as living habits after hepatitis B vaccination was still negative (immunocompromised). Results One case of HBVDNA was found in 15 cases. The conditional univariate regression analysis showed that there was significant difference between sexes, alcohol consumption history, height, weight, family history and control group (P <0.05) There are three factors in the stepwise regression analysis of conditional multi-factors into the regression equation. The sex, family history and alcohol consumption of vaccinated subjects are different. The probability of immune failure in males is 1.79 times that of females, and the probability of immune failure in family history subjects is 4.98 times that of no family history subjects. More than 2 2 drinks per week are 1.58 times of those who seldom drink. Conclusion The results of this study showed that the incidence of hepatitis B vaccine failure was affected by the level of trace HBV infection, gender, family history and alcohol consumption.