高胆固醉血症时血小板对ADP、Ad、胶原诱导的聚集反应增加,对释放剂释放反应也增加的报告已很多。一般认为系高胆固醇影响血小板膜组成及机体代谢异常所致。为了研究血小板膜流动性与释放、聚集之间的关系,选用体重为2.31～2.47kg日本大耳白雄兔,高胆固醇饲料(每日150g普通饲料中加5g胆固醇)喂养四个月后,主动脉普遍出现粥样班块。以DPH(1.6-二苯基-1,3,5-已三烯)为荧光探剂,测定血小板膜荧光偏振,标出膜微 Platelet-induced aggregation of ADP, Ad, and collagen increases in hypercholesterolemia and there have been many reports of increased release response to release agents. It is generally believed that high cholesterol affects platelet membrane composition and metabolic abnormalities in the body. In order to study the relationship between the platelet membrane fluidity and release and aggregation, the weight of 2.31-2.47kg Japanese big-eared white male rabbits was used, and the high-cholesterol diet (daily 150g normal diet plus 5g cholesterol) was fed for four months. Atherosclerosis is common in arteries. Using DPH (1.6-diphenyl-1,3,5-hexatriene) as a fluorescent probe to determine the fluorescence polarization of platelet membranes