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目的探讨慢性阻塞性肺疾病患者继发肺部真菌感染的诱因、相关因素及防治对策。方法对三门峡市第三人民医院2005年1月至2009年12月收治的慢性阻塞性肺疾病继发肺部真菌感染患者的临床资料进行回顾性分析。结果痰培养以白色念珠菌为主,给予氟康唑治疗后治愈25例,占55.56%;好转13例,占28.89%;7例死亡,病死率为15.56%,本组用药后无不良反应发生,研究结果提示慢性阻塞性肺疾病继发肺部真菌感染与广谱抗生素联合应用、糖皮质激素的应用等诱因相关。结论合理使用抗生素及糖皮质激素、提高患者免疫力是预防肺部真菌感染的关键。
Objective To explore the causes, related factors and prevention and cure strategies of secondary pulmonary fungal infection in patients with chronic obstructive pulmonary disease. Methods The clinical data of patients with pulmonary fungal infection secondary to chronic obstructive pulmonary disease admitted to the Third People’s Hospital of Sanmenxia from January 2005 to December 2009 were analyzed retrospectively. Results Candida albicans was the mainstay of sputum culture. 25 cases (55.56%) were cured after fluconazole treatment, 13 cases improved (28.89%), 7 died and the case fatality rate was 15.56%. No adverse reaction occurred in this group , The results suggest that chronic pulmonary obstructive pulmonary disease secondary pulmonary fungal infection with broad-spectrum antibiotics combined with glucocorticoid and other incentives related. Conclusion The rational use of antibiotics and glucocorticoids to improve patient immunity is the key to prevent pulmonary fungal infection.