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胃粘液中的碳酸酐酶是参与壁细胞分泌盐酸的重要的酶,动物实验已证明该酶的特异性抑制剂——醋唑磺胺可抑制泌酸和避免溃疡发生,在人类也具治疗溃疡病的作用。作者于6年中以口服醋唑磺胺25～30毫克/公斤/天治疗3,278例X线下均有壁龛的溃疡病。其中胃溃疡741例(女318例,男423例,年龄34～71岁),十二指肠溃疡2,287例(女572例,男1,715例,年龄16～62岁),幽门溃疡116例(女17例,男99例,年龄
Carbonic anhydrase in gastric mucus is an important enzyme involved in the secretion of hydrochloric acid from parietal cells. Animal experiments have demonstrated that the specific inhibitor of this enzyme, acetosulfan, can inhibit the acid secretion and prevent the occurrence of ulcers. In humans, Role. The authors treated 3,278 patients with niche ulcer disease under x-ray with oral acetosulfamide 25 to 30 mg / kg / day over 6 years. Among them, 741 cases of gastric ulcer (318 female, 423 male, age 34-71), 2,287 cases of duodenal ulcer (572 female, 1,715 male, aged 16-62), 116 cases of pyloric ulcer 17 cases, 99 males, age