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为了解乙型病毒性肝炎后肝硬化 (LC)患者外周血TNF -α与肝纤维化的关系 ,用酶联免疫法及放射免疫法分别测定其外周血中TNF -α、HPcⅢ和HA的水平。结果显示 :(1)上述指标在LC病人明显高于正常对照 (P <0 0 1) ,且各指标与肝功能变化相一致 ;(2 )TNF -α与ALT、γ -GT的变化呈正相关 ,与HPcⅢ和HA无相关性 (P >0 0 5 )。提示 :(1)TNF -α是引起肝细胞坏死的重要细胞因子 ,与LC的发生和发展有密切关系 ;(2 )LC病人的胶原代谢活跃 ,HA和HPcⅢ可反映LC的病情变化 ;(3)TNF -α在活体内不影响肝胶原代谢。
To understand the relationship between TNF-α and hepatic fibrosis in peripheral blood of patients with cirrhosis (LC) after hepatitis B virus infection, the levels of TNF-α, HPcⅢ and HA in peripheral blood were measured by enzyme-linked immunosorbent assay and radioimmunoassay . The results showed that: (1) The above indexes in LC patients were significantly higher than those in normal controls (P <0.01), and the indexes were consistent with the changes of liver function; (2) TNF-α was positively correlated with the changes of ALT and γ -GT , But not with HPcⅢ and HA (P> 0.05). It is suggested that TNF-α is an important cytokine causing hepatocyte necrosis and closely related to the occurrence and development of LC. (2) Collagen metabolism is active in patients with LC, and HA and HPcⅢ may reflect the changes of LC. (3) ) TNF-α does not affect hepatic collagen metabolism in vivo.