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目的：对比研究乳腺癌与皮肤癌转移抑制基因nm23-H1表达的意义。方法：用单克隆抗体免疫组织化学S-P法检测81例乳腺癌及109例皮肤癌。nm23-H1阳性细胞数超过30％的癌细胞定为过度表达。结果：乳腺癌中导管原位癌、无转移及有转移浸润性导管癌的过表达率分别为82％、77％和33％。皮肤癌中基底细胞癌、无转移及有转移鳞状细胞癌的过表达率分别为79％、61％和27％，差别有显著意义，P＜0005。结论：①nm23H1对皮肤癌和乳腺癌的转移同样有调控功能，但各个不同肿瘤其转移调控所需nm23－H1的数量可能不同.②基底细胞癌与鳞状细胞癌的生物学行为不同，基底细胞癌只浸润不转移，可能与基底细胞癌保留着高水平的nm23－H1有关，其转移行为可能主要由转移抑制基因凋控。
Objective: To compare the significance of the expression of nm23-H1, a metastasis suppressor gene in breast cancer and skin cancer. Methods: 81 cases of breast cancer and 109 cases of skin cancer were detected by monoclonal antibody immunohistochemical S-P method. Cancer cells with nm23-H1 positive cells exceeding 30% were overexpressed. RESULTS: Overexpression rates of ductal carcinoma in situ, non-metastasis, and metastatic invasive ductal carcinoma were 82%, 77%, and 33%, respectively. The over-expression rates of basal cell carcinoma, non-metastasis, and metastatic squamous cell carcinoma in skin cancer were 79%, 61%, and 27%, respectively, with significant difference, P<0005. Conclusion: 1 nm23H1 has the same regulatory function for the metastasis of skin and breast cancer, but the number of nm23-H1 required for metastasis and regulation of different tumors may be different. 2 The biological behaviors of basal cell carcinoma and squamous cell carcinoma are different. Basal cells Cancer infiltration does not metastasize and may be associated with high levels of nm23-H1 in basal cell carcinoma, and its metastatic behavior may be dominated by metastasis suppressor genes.