1病例患者女,28岁,曾3次怀孕,均于60d左右自然流产,后未避孕未孕,患者本人表型、智力均正常,无妇科疾患及其他疾病史,体检正常,非近亲婚配,无类似疾病家族史;丈夫一般体格检查正常。患者父母非近亲结婚,患者出生时,父亲25岁,母亲24岁,孕期无毒物接触史和用 1 case of female patients, 28 years old, had 3 pregnancies, were spontaneous abortion around 60d, after contraception and not pregnant, the patient’s own phenotype, intelligence are normal, no history of gynecological diseases and other diseases, physical examination, non- No similar family history of illness; husband’s normal physical examination. Patients were married non-relatives, the patient was born, the father 25 years old, the mother 24 years old, non-toxic during pregnancy contact history and use