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Danazol是一种人工合成的17α-乙炔睾丸酮的衍化物。近年来国外学者对于danazol的药理和临床应用进行了比较广泛的研究。为使读者对danaz01的药理和临床应用有所了解,作者参考文献综述如下。一、Danazol的药理学 Danazol是一种杂环固醇,在固醇的A环上有一个异恶唑结构(见图1)。其主要代谢产物是2-羟甲基羟脱水孕酮。人类服用danazol后两小时血浆内药物浓度最高;服药后8小时浓度就很低;长期服药达6个月时,亦无药物蓄积现象;一旦停药2天后血浆中的药物浓度迅速降低乃至不能测出。
Danazol is a synthetic 17α-ethynyl testosterone derivative. In recent years, foreign scholars on danazol pharmacology and clinical application of a more extensive study. In order to make readers understand the pharmacology and clinical application of danaz01, the author’s references are summarized as follows. Danazol’s pharmacology Danazol is a heterocyclic steroid with an isoxazole structure on the A ring of sterols (see Figure 1). Its main metabolite is 2-Hydroxymethyl Hydroxyprogesterone. After taking danazol two hours human plasma drug concentration highest; 8 hours after taking the drug is very low; long-term medication up to 6 months, there is no drug accumulation phenomenon; once discontinued two days after the rapid decline in the concentration of the drug in the plasma can not even test Out