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目的 :探讨肝细胞核因子 1α(HNF 1α)基因外显子 1Ala98Val变异是否与中国汉族迟发型 2型糖尿病相关。方法 :选择中国汉族 15 0例迟发型 2型糖尿病患者及 15 5例正常对照者 ,应用聚合酶链反应———限制性片段长度多态 (PCR SSCP)及直接测序法检测Ala98Val变异。结果 :受检者均不存在Ala98Val变异。结论 :Ala98Val变异不是引起中国汉族迟发型 2型糖尿病的重要遗传因素。
Objective: To investigate whether 1Ala98Val mutation of exon 1 of HNF 1α gene is associated with delayed type 2 diabetes in Chinese Han population. Methods: A total of 15 0 Chinese patients with delayed type 2 diabetes mellitus and 15 5 normal controls were enrolled in this study. The mutations of Ala98Val were detected by polymerase chain reaction - restriction fragment length polymorphism (PCR SSCP) and direct sequencing. Results: None of the subjects had Ala98Val mutation. Conclusion: The Ala98Val mutation is not an important genetic factor causing type 2 diabetes in late-onset Han Chinese.