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目的探讨纳洛酮与高压氧治疗中重度急性一氧化碳中毒(ACOP)的临床疗效。方法将40例中重度ACOP患者随机分为两组,每组20例。对照组给予常规治疗和单用高压氧治疗,治疗组在对照组治疗基础上给予纳洛酮治疗。比较两组疗效及相关指标。结果治疗组治愈率及有效率均高于对照组,差异有统计学意义(P<0.05);治疗组平均昏迷时间显著短于对照组,迟发性脑病发生率明显低于对照组,差异有统计学意义(P<0.05)。结论纳洛酮与高压氧治疗中重度ACOP疗效确切,可显著缩短患者昏迷时间,降低迟发性脑病的发生率。
Objective To investigate the clinical efficacy of naloxone and hyperbaric oxygen in the treatment of moderate and severe acute carbon monoxide poisoning (ACOP). Methods 40 patients with moderate to severe ACOP were randomly divided into two groups, 20 cases in each group. The control group was given conventional therapy and hyperbaric oxygen therapy alone. The treatment group was treated with naloxone on the basis of the control group. The curative effect and related indicators of two groups were compared. Results The cure rate and effective rate in the treatment group were significantly higher than those in the control group (P <0.05). The average coma time in the treatment group was significantly shorter than that in the control group, and the incidence of delayed encephalopathy was significantly lower than that in the control group Statistical significance (P <0.05). Conclusion Naloxone and hyperbaric oxygen treatment of moderate and severe ACOP exact effect, can significantly shorten the coma time and reduce the incidence of delayed encephalopathy.