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目的探讨治疗幽门螺杆菌阴性十二指肠溃疡的临床有效治疗方法。方法随机抽取100例幽门螺杆菌阴性十二指肠溃疡患者,其中50例给予奥美拉唑治疗,作为实验1组;另50例患者给予雷尼替丁治疗,作为实验2组。治疗周期为6周,观察两组患者治疗有效率及各项临床表征改善情况。结果两组患者治疗有效率分析,实验1组优于实验2组(P<0.05);治疗后两组患者腹痛、胀气、反酸、呕吐四项临床表征改善情况均明显优于治疗前(P<0.01);组间比较,实验1组优于实验2组(P<0.05)。结论对于幽门螺杆菌阴性十二指肠溃疡患者,采用奥美拉唑治疗效果更好,且安全性高,可在临床大力推广。
Objective To investigate the clinical effective treatment of Helicobacter pylori-negative duodenal ulcer. Methods A total of 100 patients with H. pylori-negative duodenal ulcer were randomly selected, of whom 50 patients were treated with omeprazole as experimental group 1 and the other 50 patients received ranitidine as experimental group 2. The treatment cycle was 6 weeks. The treatment efficiency and the clinical improvement of the two groups were observed. Results The two groups of patients with treatment efficiency analysis, the experimental group 1 was better than the experimental group 2 (P <0.05); after treatment, the two groups of patients with abdominal pain, flatulence, acid reflux, vomiting, four clinical symptoms were significantly better than before treatment (P <0.01). Compared between two groups, the experimental group 1 was better than the experimental group 2 (P <0.05). Conclusion For patients with Helicobacter pylori-negative duodenal ulcer, the use of omeprazole treatment effect is better, and high safety, can be vigorously promoted in the clinic.