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目的:探讨神经生长因子对急性脑出血患者肿瘤坏死因子-α(TNF-α)、血浆N端脑钠肽前体(NTproBNP)水平及疗效影响。方法:将2014-02-2015-09我院收治的86例急性脑出血患者随机分为干预组和常规组,常规组采用常规方法治疗,干预组在常规组基础上采用神经生长因子治疗,比较2组患者治疗前后TNF-α、NT-proBNP水平及治疗效果。结果:2组患者治疗前TNF-α、NT-proBNP水平比较差异无统计学意义;治疗后干预组患者TNF-α、NT-proBNP水平显著低于常规组[(35.4±8.9)ng/ml vs.(44.1±9.8)ng/ml,(66.4±12.4)pg/ml vs.(114.5±13.8)pg/ml,P<0.01]。干预组患者治疗总有效率显著高于常规组(97.67%vs.83.72%,P<0.05)。结论:神经生长因子治疗急性脑出血患者可降低患者TNF-α、NT-proBNP水平,提高临床治疗效果。
Objective: To investigate the effects of nerve growth factor on levels of tumor necrosis factor-α (TNF-α) and plasma NT-proBNP in patients with acute cerebral hemorrhage. Methods: A total of 86 patients with acute cerebral hemorrhage admitted to our hospital from February 2014 to November 2015 were randomly divided into intervention group and conventional group. The conventional group was treated by conventional method. The intervention group was treated with nerve growth factor on the basis of conventional group The levels of TNF-α and NT-proBNP in two groups before and after treatment and the therapeutic effect. Results: The levels of TNF-α and NT-proBNP in the two groups were not significantly different before treatment. The levels of TNF-α and NT-proBNP in the intervention group were significantly lower than those in the conventional group [(35.4 ± 8.9) ng / ml vs (44.1 ± 9.8) ng / ml, (66.4 ± 12.4) pg / ml vs. (114.5 ± 13.8) pg / ml, P <0.01]. The total effective rate of intervention group was significantly higher than that of the conventional group (97.67% vs.83.72%, P <0.05). Conclusion: NGF treatment of patients with acute cerebral hemorrhage can reduce the level of TNF-α, NT-proBNP and improve the clinical effect.