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目的:探讨大黄在小儿重症肺炎治疗中的肠道保护作用。方法:选择小儿重症肺炎60例.随机分成治疗组和对照组,均采用综合治疗,对照组按西药常规治疗,治疗组内服大黄。结果:治疗组有效率为77%(23/30).对照组有效率为50%(15/30),有统计学差异(P<0.05)。多器官功能障碍(MODS)的发生率治疗组(8/30)占27%;对照组(16/30)占57%.有统计学差异(P<0.05)。治疗组存活26例,生存率86.7%,对照组存活20例,生存率66.7%(P>0.05)。结论:大黄对肠道屏障保护在治疗小儿重症肺炎是行之有效的,可以防止病情向MODS演变及降低病死率。
Objective: To investigate the effect of rhubarb on the intestinal protection in pediatric severe pneumonia. Methods: Sixty children with severe pneumonia were selected and randomly divided into treatment group and control group, all of which were treated by combination therapy. The control group was treated routinely with western medicine, and the treatment group took rhubarb orally. Results: The effective rate was 77% (23/30) in the treatment group and 50% (15/30) in the control group, with statistical significance (P <0.05). The incidence of multiple organ dysfunction (MODS) was 27% in the treatment group (8/30) and 57% in the control group (16/30), with statistical significance (P <0.05). The treatment group survived in 26 cases, the survival rate was 86.7%, the control group survived in 20 cases, the survival rate was 66.7% (P> 0.05). CONCLUSION: Rhubarb is effective in protecting the intestinal barrier against severe pneumonia in infants, and can prevent the progression of the disease to MODS and reduce the mortality rate.