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本文采用Meta分析技术对三所医科大学关于丙型肝炎感染途径的配对病例对照研究结果(共160对)进行综合分析,以探索丙型肝炎病毒(HCV)感染的可能途径。计算合并OR值,并作χ2检验。合并结果表明:输血及血制品史、肝炎家族史、注射史、外科手术史与HCV感染关系密切(合并OR值依次为2.4、4.85、6.79、1.96)。而既往肝病史与HCV感染无关(P>0.25)。提示:在丙肝的传播中,仍以输血和血制品为主要危险因素,而其它传播途径也不可忽视。
In this paper, a meta-analysis of three pairs of case-control studies (160 pairs) on hepatitis C infection in three medical universities was conducted to analyze the possible pathways of hepatitis C virus (HCV) infection. The combined OR values were calculated and tested for χ2. The merged results showed that the history of blood transfusion and blood product, family history of hepatitis, injection history and surgical operation were closely related to HCV infection (OR = 2.4, 4.85, 6.79, 1.96 respectively). The history of previous liver disease has nothing to do with HCV infection (P> 0.25). Tip: In the spread of hepatitis C, blood transfusion and blood products are still the main risk factors, and other routes of transmission can not be ignored.