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Although the animal models of hepatic fibrosis developed by former researchers have pathological changes of hepatic fibrosis,they do not include characteristics of important TCM syndromes such as stagnation of qi,deficiency of qi,liver depression,phlegm-dampness and blood stasis because of single-factor modeling. Animal models of hepatic fibrosis and animal models integrated disease and syndrome were reviewed,and several new types of integrated disease and syndrome animal models constructed by multiple-factor modeling method were evaluated,under the guidance of etiological theory of TCM. This kind of hepatic fibrosis model animals has dual characteristics of disease and syndrome. It is consistent with pathological characteristics of hepatic fibrosis in western medicine when replicating the basic characteristics accorded with TCM syndrome. Thus,the pathogenesis and pathogenic process of clinical disease and syndrome formation is simulated more accurately,providing a new platform and pathway for studying hepatic fibrosis disease with integrated traditional Chinese and western medicine.
Although the animal models of hepatic fibrosis developed by former researchers have pathological changes of hepatic fibrosis, they do not include characteristics of important TCM syndromes such as stagnation of qi, deficiency of qi, liver depression, phlegm-dampness and blood stasis because of single- factor modeling. Animal models of hepatic fibrosis and animal models of integrated disease and syndrome were reviewed, and several new types of integrated diseases and syndrome animal models constructed by multiple-factor modeling method were evaluated, under the guidance of etiological theory of TCM. This kind of hepatic fibrosis model animals has dual characteristics of disease and syndrome. It is consistent with pathological characteristics of hepatic fibrosis in western medicine when replicating the basic characteristics accorded with TCM syndrome. Thus, the pathogenesis and pathogenic process of clinical disease and syndrome is simulated more accurately, providing a new platform and pat hway for studying hepatic fibrosis disease with integrated traditional Chinese and western medicine.